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| Single-Season RBIs Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | RBIs | PA | Year | Career Leaderboard |
| 1. | Carlos Gatton | 212 | 746 | 2004 | |
| 2. | George Selders | 196 | 793 | 2002 | |
| 3. | William Remy * | 194 | 746 | 2001 | |
| 4. | William Remy * | 189 | 741 | 2002 | |
| 5. | Andrew Stafford | 187 | 816 | 2002 | |
| Richard Berglund * | 187 | 771 | 2002 | ||
| 7. | Carlos Gatton | 180 | 735 | 2003 | |
| Joaquin Broomfield * | 180 | 770 | 2002 | ||
| 9. | Richard Berglund * | 179 | 729 | 2001 | |
| 10. | Bradley Olmos | 176 | 754 | 2002 | |
| 11. | Joaquin Broomfield * | 174 | 726 | 2004 | |
| 12. | Ralph Willis | 170 | 808 | 2004 | |
| 13. | Marcelino Prater | 169 | 707 | 2001 | |
| 14. | David Tiffany * | 168 | 743 | 2004 | |
| Darrell Stowers | 168 | 719 | 2002 | ||
| 16. | Brian Devinney * | 167 | 718 | 2010 | |
| Bradley Olmos | 167 | 729 | 2004 | ||
| 18. | Isidro Ehlers | 166 | 772 | 2002 | |
| Timothy Bohm | 166 | 728 | 2001 | ||
| 20. | Lamont Colon | 165 | 721 | 2023 | |
| Paul Maine | 165 | 710 | 2022 | ||
| 22. | Billy Westley | 164 | 699 | 2024 | |
| 23. | Darrell Stowers | 163 | 695 | 2007 | |
| Carlos Gatton | 163 | 731 | 2005 | ||
| Gary Davila | 163 | 755 | 2004 | ||
| 26. | Gregory McIntosh * | 162 | 797 | 2004 | |
| Jeff Calkins * | 162 | 736 | 2002 | ||
| 28. | Vincenzo Varga | 161 | 733 | 2021 | |
| Darrell Behm * | 161 | 728 | 2005 | ||
| 30. | Bradley Olmos | 160 | 711 | 2009 | |
| Barton Emrich * | 160 | 656 | 2002 | ||
| 32. | Wilson Cleary | 159 | 713 | 2025 | |
| Brian Rice | 159 | 650 | 2017 | ||
| David Tiffany * | 159 | 729 | 2006 | ||
| 35. | Melvin Martinez | 157 | 719 | 2017 | |
| Paul Pina * | 157 | 750 | 2002 | ||
| 37. | Gabriel Zeitler | 156 | 709 | 2010 | |
| David Tiffany * | 156 | 735 | 2008 | ||
| 39. | Richard Berglund * | 154 | 724 | 2006 | |
| William Remy * | 154 | 751 | 2004 | ||
| Pedro Boone | 154 | 736 | 2004 | ||
| Gary Frances * | 154 | 725 | 2003 | ||
| 43. | Harold Lejeune | 153 | 717 | 2024 | |
| Rocco Randazzo | 153 | 661 | 2017 | ||
| Darrell Behm * | 153 | 787 | 2002 | ||
| Michael Cadwell | 153 | 701 | 2001 | ||
| 47. | Ramon Santacruz | 152 | 718 | 2024 | |
| John Barrett | 152 | 705 | 2024 | ||
| Antonio Ohl | 152 | 733 | 2010 | ||
| William Remy * | 152 | 709 | 2007 | ||
| Paul Pina * | 152 | 749 | 2004 | ||
| George Selders | 152 | 725 | 2004 | ||
| Rick Nissen | 152 | 736 | 2002 | ||
| 54. | Keith Day | 151 | 731 | 2009 | |
| Ralph Teachout | 151 | 800 | 2004 | ||
| Darrell Stowers | 151 | 713 | 2004 | ||
| 57. | Larry Goguen * | 150 | 725 | 2007 | |
| David Tiffany * | 150 | 720 | 2007 | ||
| Richard Berglund * | 150 | 753 | 2004 | ||
| 60. | Christopher Caison | 149 | 699 | 2025 | |
| Brian Rice | 149 | 661 | 2021 | ||
| Joe Smith | 149 | 726 | 2009 | ||
| Charles Dorazio * | 149 | 692 | 2007 | ||
| Jeff Calkins * | 149 | 741 | 2004 | ||
| Robert Maddox | 149 | 689 | 2002 | ||
| 66. | James Mueller | 148 | 690 | 2023 | |
| Frankie Maestas | 148 | 716 | 2017 | ||
| Melvin Martinez | 148 | 716 | 2016 | ||
| George Selders | 148 | 713 | 2005 | ||
| Gregory McIntosh * | 148 | 720 | 2001 | ||
| 71. | Frankie Maestas | 147 | 691 | 2018 | |
| Gregory McIntosh * | 147 | 750 | 2009 | ||
| Gayle Robicheaux * | 147 | 718 | 2007 | ||
| Brian Devinney * | 147 | 741 | 2005 | ||
| Isidro Ehlers | 147 | 762 | 2004 | ||
| Freddie Wiens * | 147 | 750 | 2004 | ||
| Brian Devinney * | 147 | 748 | 2004 | ||
| Brian Devinney * | 147 | 697 | 2003 | ||
| John Dewall | 147 | 723 | 2002 | ||
| 80. | Paul Pina * | 146 | 707 | 2007 | |
| Isidro Ehlers | 146 | 737 | 2005 | ||
| Carlos Gatton | 146 | 689 | 2002 | ||
| 83. | Gabriel Leasure | 145 | 738 | 2024 | |
| Joan Sprouse | 145 | 730 | 2023 | ||
| Maury Declark | 145 | 703 | 2021 | ||
| Harold Lejeune | 145 | 702 | 2021 | ||
| Terry Helmuth | 145 | 690 | 2015 | ||
| John Johnson * | 145 | 727 | 2010 | ||
| Charles Dorazio * | 145 | 741 | 2009 | ||
| Tony Ehmann * | 145 | 739 | 2007 | ||
| Paul Pina * | 145 | 733 | 2005 | ||
| Richard Berglund * | 145 | 682 | 2005 | ||
| Daniel Berman | 145 | 753 | 2004 | ||
| Burt Brooke | 145 | 801 | 2002 | ||
| Vernon James | 145 | 588 | 2002 | ||
| Carlos Gatton | 145 | 682 | 2001 | ||
| Gary Frances * | 145 | 637 | 2001 | ||
| 98. | Juan Torres | 144 | 718 | 2023 | |
| Carlos Gatton | 144 | 553 | 2009 | ||
| Gregory McIntosh * | 144 | 726 | 2008 |
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